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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Agricultural and Food Chemistry
2007
Nov
;
(23)
:0
Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot.
Li CY
,
Tsai WJ
,
Damu AG
,
Lee EJ
,
Wu TS
,
Dung NX
,
Thang TD
,
Thanh L
Abstract
The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.
DHARA ID:
D014968
Pubmed ID:
17941696
Access to Full Paper Not Available
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