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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Natural Products
2007
Dec
;
(12)
:0
Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents.
Kuo PC
,
Shen YC
,
Yang ML
,
Wang SH
,
Thang TD
,
Dung NX
,
Chiang PC
,
Lee KH
,
Lee EJ
,
Wu TS
Abstract
Cytotoxicity-guided phytochemical investigation of a methanolic extract of Croton tonkinensis afforded two new kaurane diterpenoids (1, 2) and 10 known ent-kaurane-type diterpenoids (3- 12). The structures of 1 and 2 were based on analysis of spectroscopic and mass spectral data. Compounds 3- 12 were identified by comparison of their spectroscopic and physical data with those reported in the literature. Selected compounds from this plant were examined for cytotoxic and anti-inflammatory activities. Compounds 4 and 9 showed the highest cytotoxic activity against the tested tumor cell lines. Compounds 3, 4, 6, 8, 9, and 11 had IC 50 values less than 5 microM and were more potent than the nonspecific NOS inhibitor L-NAME in inhibiting LPS-induced NO production.
DHARA ID:
D014013
Pubmed ID:
18161942
Access to Full Paper Not Available
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