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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Drug Research in Ayurvedic Sciences
2018
January- March
;
3
(1)
:15-22
Evaluation of Safety of Karnasphota (Cardiospermum halicacabum L.) Leaf through Acute Oral Toxicity Study and Repeated Dose: 28-day Oral Toxicity Study in Wistar Albino Rats
Natarajan Thamizhselvam (1)
,
Kandiyoor R Surabhi (2)
,
Yalwar R Sanjayakumar (3)
,
Kannanamkulam G Vasanthakumar (3)
,
Sudesh N Gaidhani (4)
,
Paravazhi Radhakrishnan (5)
1. Assistant Director, National Ayurveda Research Institute for Panchakarma Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Cheruthuruthy, Kerala, India 2. Senior Research Fellow, National Ayurveda Research Institute for Panchakarma Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Cheruthuruthy, Kerala, India 3. Assistant Director, National Ayurveda Research Institute for Panchakarma, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH Cheruthuruthy, Kerala, India 4. Assistant Director (Pharmacology), Central Council for Research in Ayurvedic Sciences, New Delhi, India 5. Assistant Director In-Charge and Head, National Ayurveda Research Institute for Panchakarma Cheruthuruthy, Kerala, India
Abstract
Aim: Cardiospermum halicacabum L. is a climbing plant under Sapindaceae family. The plant leaf is used by traditional healers for treatment of various illnesses. Considering the ethno-medicinal value of C. halicacabum, the present study was taken up to evaluate single-dose acute toxicity study and repeated dose 28-day oral toxicity study (subacute) in Wistar albino rats. Materials and methods: The hydroalcoholic extract of C. halicacabum leaf was administered orally to Wistar rats as single dose (2000 mg/kg bwt) in acute toxicity study and for continuous 28 days in repeated dose subacute toxicity study at three dose levels (250, 500, and 1000 mg/kg bwt). The study was carried out as per Organisation for Economic Cooperation and Development (OECD) guidelines 423 and 407. Animal mortality and general behavior were observed during the study period. Results: The study showed that there were no mortality and morbidity in the test groups. The detailed biochemical and hematological investigations evaluated in control and test groups evidenced the safety of the extract as there were no significant differences among control and test groups. Histopathology study in vital organs of test groups showed no significant abnormalities. Conclusion: The study concluded that the hydroalcoholic extract of C. halicacabum was safe at the prescribed dosages in Wistar albino rats. Clinical significance: As the safety dosage of the hydroalcoholic extract of C. halicacabum has been proved in Wistar rats, further studies on biological efficacy or biopotency studies can be taken up using these details. Keywords: Acute and repeated dose 28-day oral toxicity study, Balloon vine, Cardiospermum halicacabum.
DHARA ID:
D060730
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