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Journal of Drug Research in Ayurvedic Sciences 2017 October - December ; 2 (4) :281-288
Evaluation of Hypolipidemic Activity of Cardiospermum halicacabum L. Leaf in Atherodiet-induced Wistar Albino Rats
Natarajan Thamizhselvam (1), Natarajan Thamizhselvam (1), Kandiyoor R Surabhi (2), Kandiyoor R Surabhi (2), Yalwar R Sanjayakumar (3), Yalwar R Sanjayakumar (3), Kannanamkulam KG Vasanthakumar (3), Kannanamkulam KG Vasanthakumar (3), Sudesh N Gaidhani (4), Sudesh N Gaidhani (4), Paravazhi Radhakrishnan (5), Paravazhi Radhakrishnan (5)
1. Assistant Director,Central Council for Research in Ayurvedic Sciences, National Ayurveda Research Institute for Panchakarma, Thrissur, Kerala India 2. Senior Research Fellow, 6Department of Biochemistry, National Ayurveda Research Institute for Panchakarma, Thrissur, Kerala, India 3. Assistant Director, Department of Biochemistry, National Ayurveda Research Institute for Panchakarma, Thrissur, Kerala, India 4. Assistant Director and Program Officer, Central Council for Research in Ayurvedic Sciences, National Ayurveda Research Institute for Panchakarma, Thrissur, Kerala India 5. Assistant Director In-Charge and Head, Department of Biochemistry, National Ayurveda Research Institute for Panchakarma, Thrissur, Kerala, India
Abstract
Aim: Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. The present study has been taken up to evaluate hypolipidemic activity of hydro alcoholic extract of Cardiospermum halicacabum L. leaf, as this plant is widely used by the local healers of South India for treatment of various illnesses. Materials and methods: The experiment was carried out in atherodiet-induced hyperlipidemia in Wistar Albino rats. The experiment duration was 28 days and it comprised six groups, such as healthy control, extract control, disease control, treatment group low dose, treatment group high dose, and standard drug (SD). The biochemical investigations including lipid profile with Atherogenic Index and Coronary Risk Index, and other metabolic parameters were evaluated using standard protocols. Histopathology studies for vital organs of animals were also carried out. Results: The study showed that the hydroalcoholic extract of C. halicacabum L. leaf has significant hypolipidemic activity in the atherodiet-induced hyperlipidemia in Wistar rats when compared with the disease control group. The histopathology study also evidenced the safety of the extract. Conclusion: The study concluded that the hydroalcoholic extract of C. halicacabum L. has significant hypolipidemic activity at the prescribed dosages. Clinical relevance: As the plant has shown promising effect in the aspect of hypolipidemic activity, further studies have to be carried out for developing of new product as single drug and in the formulations of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy) system of medicines for management of hyperlipidemia Keywords: Atherodiet, Cardiospermum halicacabum, Hypolipidemic activity.
DHARA ID: D060723
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