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Journal of Research in Ayurvedic Sciences 2020 October - December ; 4 (4) :139-148
Clinical Safety of Selected Ayurvedic Formulations in Osteoarthritis
Sunita Mata (1), Sunita Mata (1), Shruti Khanduri (1), Shruti Khanduri (1), Sarada Ota (1), Sarada Ota (1), Pradeep Dua (2), Pradeep Dua (2), Babita Yadav (1), Babita Yadav (1), Savita Sharma (3), Savita Sharma (3), Hemant Panigrahi (4), Hemant Panigrahi (4), Puthanveetil Kesavan Sudarsanan Nair (5), Puthanveetil Kesavan Sudarsanan Nair (5), Tapsi Borah (6), Tapsi Borah (6), Deepa Makhija (4), Deepa Makhija (4), Radhakrishnan (7), Radhakrishnan (7), Dinesh Baruah (8), Dinesh Baruah (8), Anil Mangal (1), Anil Mangal (1), Uday Ravi Sekhar Namburi (1), Uday Ravi Sekhar Namburi (1), Maha Meda Rao (9), Maha Meda Rao (9), Veliparambil Chandran Deep (8), Veliparambil Chandran Deep (8), Pramila Devi (10), Pramila Devi (10), Shubhashree Thejasvi (11), Shubhashree Thejasvi (11), D Ankush (12), D Ankush (12), Ankush Jadhav (13), Ankush Jadhav (13), AJV Sai Prasad (13), AJV Sai Prasad (13), Kishore Kumar (11), Kishore Kumar (11), Vinod K Lavaniya (1), Vinod K Lavaniya (1), V Rakesh Narayanan (1), V Rakesh Narayanan (1), Rakesh Rana (1), Rakesh Rana (1), Richa Singhal (1), Richa Singhal (1), Bharti Gupta (4), Bharti Gupta (4), Madan Mohan Padhi (1), Madan Mohan Padhi (1), Narayanam Srikanth (1), Narayanam Srikanth (1)
1. Central Council for Research in Ayurvedic Sciences, New Delhi, India 2. Ministry of AYUSH, New Delhi, India 3. Regional Ayurveda Research Institute for Mother and Child Health, Nagpur, Maharashtra, India 4. Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India 5. Regional Ayurveda Research Institute for Lifestyle-related Disorder, Thiruvananthapuram, Kerala, India 6. Regional Ayurveda Research Institute, Itanagar, Arunachal Pradesh, India 7. National Ayurveda Research Institute for Panchakarma, Cheruthuruthy, Kerala, India 8. Central Ayurveda Research Institute for Drug Development, Kolkata, West Bengal, India 9. Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneswar, Odisha, India 10. Captain Srinivasa Murthy Regional Ayurveda Research Institute for Drug Development, Chennai, Tamil Nadu, India 11. Regional Ayurveda Research Institute for Metabolic Disorders, Bengaluru, Karnataka, India 12. Regional Ayurveda Research Institute for Drug Development, Aamkho, Gwalior, Madhya Pradesh, India 13. Regional Ayurveda Research Institute for Skin Disorders, Vijayawada, Andhra Pradesh, India
Abstract
Background: Osteoarthritis (OA) is one of the most common forms of arthritis which is caused by the degeneration of joint cartilage. It is often associated with disability and leads to impairment of quality of life. The clinical picture is similar to the disease Sandhigatavata described in Ayurveda (one among the Vatavyadhi) and is characterized by symptoms such as Sandhi Shoola (joint pain), Sandhishopha (swelling of joint), and Prasarana-Akunchana-Ashakti (difficulty in movements of the joint). The safety of 10 Ayurvedic classical formulations most commonly used in OA was clinically evaluated and the findings are provided in this article. Aim and objective: Critical analysis of clinical safety outcomes of classical Ayurvedic formulations, viz. Vatari Guggulu, Yogaraj Guggulu, Punarnava Guggulu, Maharasnadi Kwatha, Dashmoola Ghrita, Narayan Taila, Kottamchukkadi Taila, Gandharvahasta Taila, Dhanwantara Taila, and Ksheerbala Taila in patients of OA, generated through studies at different Institutes of Central Council for Research in Ayurvedic Sciences (CCRAS). Materials and methods: Data collected from four different clinical studies completed in multiple centers of CCRAS were retrospectively evaluated to assess the safety profile of 10 formulations that are commonly used in OA. Evaluation of safety was done by analyzing liver function tests (LFT) and renal function tests (RFT) before and after the trial period. Paired sample t-test was used to compare mean change from baseline to the 84th day. A p value of <0.05 was considered significant. Conclusion: The findings in four different clinical studies reveal that all ten formulations are clinically safe in patients belonging to various age groups, gender, geographical area, and Prakriti. Keywords: Dashmoola ghrita, Maharasnadi kwatha, Pharmacoepidemiology, Punarnava guggulu, Vatari guggulu, Yogaraj guggulu.
DHARA ID: D060624
Link To Full Paper

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