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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Chemical and Pharmaceutical Bulletin
1998
Aug
;
46
(8)
:1339-40
Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata.
Yoshikawa M
,
Murakami T
,
Yashiro K
,
Matsuda H
Abstract
A potent natural alpha-glucosidase inhibitor called kotalanol has been isolated from an antidiabetic traditional Ayurvedic medicine, the roots and stems of Salacia reticulata Wight, through bioassay-guided separation. The structure of kotalanol was elucidated on the basis of chemical and physicochemical evidence to be the inner salt comprised of 1-deoxyheptosyl-3-sulfate anion and 1-deoxy-4-thio-D-arabinofuranosyl sulfonium cation. Kotalanol was found to show more potent inhibitory activity against sucrase than salacinol and acarbose.
DHARA ID:
D003406
Pubmed ID:
9734318
Access to Full Paper Not Available
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