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Journal of Research in Ayurvedic Sciences 2019 April - June ; 3 (2) :48-54
Evaluation of Gokshuradi Guggulu and Guduchi Churna in the Management of Type II Diabetes Mellitus (Madhumeha)

Abstract
Background: Diabetes mellitus (DM) has become an increasing global health problem among all socioeconomic groups, leading to various complications such as nephropathy, neuropathy, and retinopathy which are responsible for morbidity and mortality. Ayurvedic approach to pathogenesis of Madhumeha can provide solution in managing the incidence of diabetes among population by using various preparations. Gokshuradi Guggulu and Guduchi Churna are such Ayurvedic preparations. Objective: The objective of the study was to assess the clinical efficacy and safety of Gokshuradi Guggulu and Guduchi Churna in the management of type II DM using Diabetes Symptom Questionnaire (DSQ) score, short-form health survey (SF-36) score, and laboratory investigation. Materials and methods: It was an open-label, prospective, clinical trial conducted on 50 patients of type II DM (Madhumeha). Gokshuradi Guggulu 1 g (two tablets of 500 mg) twice daily after food (chew the tablets before swallowing) and Guduchi Churna 3 g twice daily after food with lukewarm water for 12 weeks were given to all study participants. The DSQ was assessed with the help of Visual Analog Scale (VAS; 0–10). Health-related quality of life was recorded at baseline and end of the 84th day by using RAND-36 items SF-36 questionnaire. In laboratory investigations, blood sugar levels, hematological parameters, renal function tests, liver function test, lipid profile, and glycated hemoglobin (HbA1c) were performed at baseline and at the end of 84th day for efficacy and safety evaluation of the drugs. Results: The DSQ score and clinical symptoms reduced significantly from baseline to the end of the treatment in 50 subjects aged between 30 years and 60 years of both sexes. The RAND SF-36 health survey showed an improvement in quality of life of all the participants. Conclusion: This study demonstrated the effectiveness of Gokshuradi Guggulu along with Guduchi Churna in the management of type II DM. Keywords: Gokshuradi Guggulu, Guduchi Churna, Madhumeha, Type II diabetes mellitus.

DHARA ID: D059617


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