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Journal of Research in Ayurvedic Sciences 2019 January- March ; 3 (1) :12-16
Efficacy of Ayurvedic Interventions in Rheumatoid Arthritis: Protocol for Systematic Review

Abstract
Introduction: Rheumatoid arthritis (RA) has been treated in Ayurveda, and substantial work has been done in studying the role of Ayurveda interventions in its management. A systematic review is planned to investigate the safety and efficacy of Ayurveda interventions for RA through analyzing published clinical research work. Materials and methods: This study is intended to systematically review the existing published clinical work including randomized controlled trials (RCTs), controlled clinical trials, parallel-group trials, and single-group clinical studies for Ayurveda interventions for RA. Electronic search of the following databases will be performed: PubMed, AYUSH research portal, digital helpline for Ayurveda research articles (DHARA), Google Scholar, the Cochrane Library (the Cochrane Database of systematic reviews, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Cochrane Methodology Register), Ayurveda college/Universities websites, databases for dissertation works without any restriction of publication year. Hand search and snowballing of studies will also be performed to fetch complete available literature. The selection of the studies, data abstraction, and validations will be performed independently by two teams of researchers. Conclusion will be derived with consensus of complete review team. Study selection will follow the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, and study quality will be assessed by CONSORT checklist for RCTs, Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) checklist for nonrandomized controlled trial (NRCTs), and CONSORT extension for Pilot and feasibility studies for pilot studies. Risk of bias assessment will be performed with the help of Cochrane RoB2 tool for RCTs and Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool for NRCTs. If sufficient and appropriate data are available, a meta-analysis will be conducted. Subgroup and sensitivity analyses will be performed if found to be necessary and feasible. Ethics and dissemination: Formal ethical approval is not required as primary data will not be collected. The results will be disseminated through a peer-reviewed publication. The review will be updated to inform and guide healthcare practice and policy. Trial Registration Number: International Prospective Register for Systematic Reviews (PROSPERO) number 2019 CRD42019133722. Keywords: Amavata, Protocol for a systematic review and meta-analysis, Vatarakta.

DHARA ID: D059610


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