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Journal of Research in Ayurvedic Sciences 2017 October - December ; 1 (4) :238-,246
Clinical Evaluation of Classical Ayurvedic Formulations Simhanada Guggulu and Brihat Saindhavadi Taila in the Management of Rheumatoid Arthritis (Amavata): A Multicentric Open Label Prospective Study
Valiparambil C Deep (1), Valiparambil C Deep (1), Sangeeta Sangvikar (2), Sangeeta Sangvikar (2), Sunita (3), Sunita (3), Sophia Jameela (4), Sophia Jameela (4), Shweta Chaudhary (5), Shweta Chaudhary (5), Bhagwan S Sharma (4), Bhagwan S Sharma (4), Shruti Khanduri (5), Shruti Khanduri (5), Babita Yadav (5), Babita Yadav (5), Pradeep Dua (6), Pradeep Dua (6), Bhogavalli CS Rao (7), Bhogavalli CS Rao (7), Rakesh Rana (8), Rakesh Rana (8), Richa Singhal (9), Richa Singhal (9), Bharti (10), Bharti (10), Madan M Padhi (11), Madan M Padhi (11), Narayanam Srikanth (12), Narayanam Srikanth (12), Kartar S Dhiman (13), Kartar S Dhiman (13)
1. Research Officer (Ayurveda), Central Ayurveda Research Institute for Neuromuscular & Musculoskeletal Disorders, Cheruthuruthy, Kerala, India 2. Research Officer (Ayurveda), Regional Ayurveda Institute for Fundamental Research, Pune Maharashtra, India 3. Research Officer (Ayurveda),6Central Council for Research in Ayurvedic Sciences New Delhi, India 4. Research Officer (Ayurveda),Central Council for Research in Ayurvedic Sciences New Delhi, India 5. Research Officer (Ayurveda),Central Council for Research in Ayurvedic Sciences New Delhi, India 6. Research Officer (Ayurveda), Ministry of AYUSH, New Delhi, India 7. Research Officer (Ayurveda), Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India 8. Statistical Officer (Statistics), Central Council for Research in Ayurvedic Sciences New Delhi, India 9. Senior Statistical Assistant (Statistics),Central Council for Research in Ayurvedic Sciences New Delhi, India 10. Assistant Director (Ayurveda),Central Council for Research in Ayurvedic Sciences New Delhi, India 11. Senior Consultant (Ayurveda),Central Council for Research in Ayurvedic Sciences New Delhi, India 12. Deputy Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences New Delhi, India 13. Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences New Delhi, India
Abstract
Introduction: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory autoimmune disease associated with articular, extra-articular, and systemic effects. Similar symptoms are found in Amavata described in Ayurveda. Simhanada Guggulu and Brihat Saindhavadi Taila are classical formulations that are used commonly in the management of Amavata. Aims and objectives: To assess the clinical efficacy and safety of the classical Ayurvedic formulations Simhanada Guggulu and Brihat Saindhavadi Taila in patients with RA. Materials and methods: A prospective, open label, multicenter study was carried out at two peripheral centers of the Central Council for Research in Ayurvedic Sciences (CCRAS). A total of 111 patients were administered Simhanada Guggulu and Brihat Saindhavadi Taila in the dose of 1.5 gm (3 tablets of 500 mg each) twice daily after food with lukewarm water and local application twice a day respectively, for a period of 12 weeks. Clinical assessment of symptoms, disease activity score-28 (DAS-28), short form 36 (SF-36), and disability index scoring were done at the baseline and at every subsequent visit at an interval of 14 days up to the 12th week and also in the follow-up without medication at the end of the 14th week. Paired sample t-test was used to compare mean change from baseline to 12th and 14th week respectively. Results: At the end of 12 weeks, statistically significant changes in symptoms, DAS 28, SF-36, and disability index score with p-value <0.001 were observed, compared with baseline. No adverse drug reaction (ADR)/adverse events (AEs) were reported during and after the trial. Conclusion: Simhanada Guggulu and Brihat Saindhavadi Taila administered together in the above-mentioned dose were found effective, safe, and tolerable in patients with RA. Keywords: Amavata, Brihat saindhavadi taila, Rheumatoid Arthritis, Simhanada Guggulu.
DHARA ID: D059578
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