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Journal of Research in Ayurvedic Sciences 2017 October - December ; 1 (4) :231-237
Clinical Efficacy and Safety of “Vasavaleha” in the Management of Stable Chronic Bronchitis: A Prospective Open Label Multicenter Study
Milind Suryavanshi (1), Milind Suryavanshi (1), Hari ML Meena (2), Hari ML Meena (2), G Babu (3), G Babu (3), Babita Yadav (4), Babita Yadav (4), Shweta Chaudhary (5), Shweta Chaudhary (5), Uday RS Namburi (6), Uday RS Namburi (6), Anu Bhatnagar (7), Anu Bhatnagar (7), Varanasi Subhose (8), Varanasi Subhose (8), Shruti Khanduri (4), Shruti Khanduri (4), Bhagwan S Sharma (9), Bhagwan S Sharma (9), Rakesh Rana (10), Rakesh Rana (10), Kartar S Dhiman (11), Kartar S Dhiman (11)
1. Assistant Director (Ayurveda), Regional Ayurveda Research Institute for Mother and Child Health, Nagpur, Maharashtra, India 2. Research Officer (Ayurveda),M.S. Regional Ayurveda Research Institute for Endocrine Disorders, Jaipur, Rajasthan, India 3. Assistant Director (Ayurveda), Regional Ayurveda Research Institute for Skin Disorders Vijayawada, Andhra Pradesh, India 4. Research Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 5. Research Officer (Research), Central Council for Research in Ayurvedic Sciences, New Delhi, India 6. Research Officer (Ayurveda), Regional Ayurveda Research Institute for Mother and Child Health, Nagpur, Maharashtra, India 7. Research Officer (Ayurveda), 7M.S. Regional Ayurveda Research Institute for Endocrine Disorders, Jaipur, Rajasthan, India 8. Research Officer (Ayurveda), Regional Ayurveda Research Institute for Skin Disorders Vijayawada, Andhra Pradesh, India 9. Research Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 10. Statistical Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 11. Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India
Abstract
Introduction: Chronic bronchitis is one of the common clinical problems seen in middle–older age group and occurs as a result of inflammation and swelling of the lining of the airways, leading to narrowing and obstruction generally resulting in persistent cough, associated with wheezing, chest pain, and shortness of breath. Chronic bronchitis can be symptomatically compared with Kasa Roga in Ayurveda. Aims and objectives: To evaluate the efficacy and safety of Vasavaleha in patients suffering from stable chronic bronchitis (CB). Materials and methods: A prospective, open label multicenter study was carried out at three peripheral units under intramural clinical research program from 2012 to 2013. One hundred and twenty six patients satisfying the selection criteria were enrolled at the Outpatient Department of the centers and were administered Vasavaleha (10 gm) twice daily after food with water for 12 weeks. Follow-up was done finally after 2 weeks without medication. Laboratory parameters were assessed at baseline, 42nd day, and at the end of the treatment period of 12 weeks (i.e., 84th day). Paired sample t-test was used to compare mean change from baseline to the 84th day. A p-value of <0.05 was considered significant. Results: At the end of 12 weeks, statistically significant improvement was observed in clinical symptoms of CB and also in peak expiratory flow rates (PEFR), forced expiratory volume (FEV1), and St. George Respiratory Questionnaire (SRGQ) Score (p < 0.001). The treatment was found to be safe and effective in the patients of CB as all the safety parameters were within the normal range. No adverse drug reaction or adverse event was reported during the trial period. Conclusion: Vasavaleha in the above prescribed dose is found to be effective and safe in the management of stable CB. Keywords: Kasa roga, St. George Respiratory Questionnaire, Stable chronic bronchitis, Vasavaleha.
DHARA ID: D059577
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