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Journal of Research in Ayurvedic Sciences 2017 October - December ; 1 (4) :223- 230
Clinical Safety of Selected Ayurvedic Formulations in Common Eye Diseases
Shruti Khanduri (1), Shruti Khanduri (1), Sarada Ota (2), Sarada Ota (2), Alok Srivastava (3), Alok Srivastava (3), Mridula Dua (4), Mridula Dua (4), Deepa Makhija (4), Deepa Makhija (4), Pradeep Dua (2), Pradeep Dua (2), Babita Yadav (5), Babita Yadav (5), Vanmala B Wakode (2), Vanmala B Wakode (2), Rakesh Rana (6), Rakesh Rana (6), Richa Singhal (7), Richa Singhal (7), Narayanam Srikanth (8), Narayanam Srikanth (8)
1. Research Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 2. Research Officer (Ayurveda),Central Council for Research in Ayurvedic Sciences, New Delhi, India 3. Research Officer (Ayurveda),Regional Ayurveda Research Institute for Eye Diseases Lucknow, Uttar Pradesh, India 4. Research Officer (Ayurveda),Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India 5. Research Officer (Ayurveda),Central Council for Research in Ayurvedic Sciences, New Delhi, India 6. Statistical Officer (Statistical), Central Council for Research in Ayurvedic Sciences, New Delhi, India 7. Statistical Assistant (Statistical), Central Council for Research in Ayurvedic Sciences, New Delhi, India 8. Deputy Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India
Abstract
Introduction: Allergic conjunctivitis (AC), dry eye syndrome (DES), and computer vision syndrome (CVS) are few of the eye diseases that commonly affect the working class. Allergic conjunctivitis is often associated with Kaphaja abhishyanda. Dry eye syndrome is caused due to chronic lack of sufficient lubrication and moisture on the surface of the eye. The CVS is a visual complaint that is clinically similar to DES. In Ayurveda, the symptoms of DES can be included under the spectrum of two different diseases, Krichronmeela and suskakshipaka. Tarpana, Aschyotana, Nasya, and oral use of Ayurvedic medicines are commonly advocated for eye diseases. Objective: Critical analysis and presentation of clinical safety and efficacy outcomes of classical Ayurvedic formulations, viz., Mahatriphaladya ghrita, Triphala kwatha, and Anu taila, in patients of common eye diseases. Materials and methods: Data were collected from three different clinical studies, viz., AC, DES, and CVS, that have been completed in peripheral institutes of Central Council for Research in Ayurvedic Sciences (CCRAS) and were critically evaluated to assay the safety profile of three drugs. Clinical safety assessments were done through analyzing liver function tests (LFTs) and kidney function tests (KFTs) before and after the trial period. Paired sample t-test was used to compare the mean changes from baseline to the end of the trial period. The study revealed that all the parameters were within the specified limits during the entire period. Conclusion: The findings in the three different clinical studies clearly reveal that Mahatriphaladya ghrita, Triphala kwath, and Anu taila are clinically safe, effective, and tolerable in common eye diseases. Keywords: Allergic conjunctivitis, Anu taila, Computer vision syndrome, Dry eye syndrome, Mahatriphaladya ghrita, Triphala kwath
DHARA ID: D059576
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