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Journal of Research in Ayurvedic Sciences 2017 April - June ; 1 (2) :117-124
Clinical Efficacy and Safety of Navayasa Churna in the Management of Iron Deficiency Anemia
Babita Yadav (1), Babita Yadav (1), BR Meena (2), BR Meena (2), Omraj Sharma (3), Omraj Sharma (3), Harbans Singh (4), Harbans Singh (4), SK Sharma (5), SK Sharma (5), VB Kumavat (6), VB Kumavat (6), Rajesh Sannd (7), Rajesh Sannd (7), GC Bhuyan (8), GC Bhuyan (8), Rakesh Rana (9), Rakesh Rana (9), Richa Singhal (10), Richa Singhal (10), Shruti Khanduri (1), Shruti Khanduri (1), Bhagwan Sahai Sharma (1), Bhagwan Sahai Sharma (1), Sophia Jameela (1), Sophia Jameela (1), Adarsh Kumar (11), Adarsh Kumar (11), Narayanam Srikanth (12), Narayanam Srikanth (12)
1. Research Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 2. Research Officer (Ayurveda),Ministry of AYUSH, New Delhi, India 3. Assistant Director (Ayurveda), Regional Ayurveda Research Institute for Nutritional Disorders, Mandi, Himachal Pradesh, India 4. Research Officer (Ayurveda), Central Ayurveda Research Institute for Respiratory Disorders Patiala, Punjab, India 5. Assistant Director (Ayurveda),Regional Ayurveda Research Institute for Nutritional Disorders, Mandi, Himachal Pradesh, India 6. Research Officer (Ayurveda), M.S. Regional Ayurveda Research Institute for Nutritional Disorders, Jaipur, Rajasthan, India 7. Assistant Director (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 8. Research Officer (Ayurveda), Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneshwar, Odisha, India 9. Statistical Officer (Statistics),Central Council for Research in Ayurvedic Sciences, New Delhi, India 10. Senior Statistical Assistant (Statistics),Central Council for Research in Ayurvedic Sciences, New Delhi, India 11. Assistant Director (Ayurveda),Central Council for Research in Ayurvedic Sciences, New Delhi, India 12. Deputy Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India
Abstract
Introduction: Iron deficiency anemia (IDA) is a condition where deficiency of iron in the body leads to reduction in the number of red blood cells (RBC). Even though IDA is an easily manageable condition with excellent outcome, it is observed that modern iron preparation often irritates gastric mucosa and causes adverse effects. In Ayurveda, IDA can be correlated with pandu based on symptomatic similarity. Navayasa Churna is an iron containing herbomineral preparation used for the management of Pandu. In this study, clinical efficacy and safety of Navayasa Churna has been evaluated in IDA. Aims and objectives: To evaluate clinical efficacy and safety of Navayasa Churna in IDA. Materials and methods: An open-labeled multicenter prospective clinical trial was conducted at Ayurveda Regional Research Institute, Mandi; M.S. Regional Ayurveda Central Research Institute, Jaipur; and the National Institute of Ayurvedic Pharmaceutical Research, Patiala. Patients with IDA (n = 150) belonging to either sex, with hemoglobin in the range of 8 to 10%, aged between 18 and 50 years and with serum ferritin <30 mg/dL, and blood smear depicting microcytic, hypochromic state were selected. Navayasa Churna was given 1 gm (2 capsules of 500 mg each) twice daily with water for 90 days with a follow-up period of 1 month without drug. Assessment was done based on the relief in clinical symptoms of IDA and hematological parameters. Safety assessment was done through analysis of liver function tests (LFTs) and kidney function tests (KFTs) before and after the trial period. Results: The formulation showed significant relief in cardinal symptoms of anemia and also in hemoglobin level. No adverse events/effects were was noted during trial period. The values of LFT and KFT were observed to be within limits during the entire period. Conclusion: Navayasa Churna in the above-mentioned dose and duration was found effective and safe in patients suffering from IDA. Keywords: Hemoglobin, Iron deficiency anemia, Navayasa Churna, Pandu.
DHARA ID: D059563
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