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Journal of Research in Ayurvedic Sciences 2017 April - June ; 1 (2) :108 - 116
Clinical Safety of Selected Ayurvedic Formulations in Rheumatoid Arthritis
Sunita (1), Sunita (1), Shruti Khandur (2), Shruti Khandur (2), Babita Yadav (1), Babita Yadav (1), Pradeep Dua (3), Pradeep Dua (3), VC Deep (4), VC Deep (4), Bikratan Das (5), Bikratan Das (5), Sangeeta Sangvikar (6), Sangeeta Sangvikar (6), Shashi Ghosh (7), Shashi Ghosh (7), AK Jain (8), AK Jain (8), GK Swami (9), GK Swami (9), T Maheswar (10), T Maheswar (10), Saiprasad (11), Saiprasad (11), Alok Srivastav (1), Alok Srivastav (1), DS Sahu (12), DS Sahu (12), Tapasi Borah (13), Tapasi Borah (13), MM Rao (14), MM Rao (14), Renu Makhija (15), Renu Makhija (15), VB Kumawat (16), VB Kumawat (16), Pitta Srinivas (17), Pitta Srinivas (17), KK Singh (18), KK Singh (18), SK Mehar (19), SK Mehar (19), Dinesh Baruah (12), Dinesh Baruah (12), Rajesh Kumari (10), Rajesh Kumari (10), Rakesh Rana (20), Rakesh Rana (20), Richa Singhal (21), Richa Singhal (21), Narayanam Srikanth (22), Narayanam Srikanth (22)
1. Research Officer (Ayurveda),Central Council for Research in Ayurvedic Sciences New Delhi, India 2. Research Officer (Ayurveda),Central Council for Research in Ayurvedic Sciences New Delhi, India 3. Research Officer (Ayurveda), Ministry of AYUSH, New Delhi, India 4. Research Officer (Ayurveda), Regional Ayurveda Research Institute for Skin Disorders Vijayawada, Andhra Pradesh, India 5. Research Officer (Ayurveda), Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneswar, Odisha, India 6. Research Officer (Ayurveda),Regional Ayurveda Institute for Fundamental Research, Pune Maharashtra, India 7. Assistant Director (Ayurveda), Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India 8. Research Officer (Ayurveda),Ministry of AYUSH, New Delhi, India 9. Assistant Director (Ayurveda),Regional Ayurveda Research Institute for Eye Diseases Lucknow, Uttar Pradesh, India 10. Research Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences New Delhi, India 11. Research Officer (Ayurveda),Regional Ayurveda Research Institute for Skin Disorders Vijayawada, Andhra Pradesh, India 12. Research Officer (Ayurveda),Central Ayurveda Research Institute for Drug Development Kolkata, West Bengal, India 13. Assistant Director (Ayurveda),Regional Ayurveda Research Institute, Gangtok, Sikkim, India 14. Director (Institute), Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneswar, Odisha, India 15. Assistant Director (Pathology), Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India 16. Research Officer (Ayurveda), M.S. Regional Ayurveda Research Institute for Endocrine Disorders, Jaipur, Rajasthan, India 17. Research Officer (Ayurveda),Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, Chennai, Tamil Nadu, India 18. Assistant Director (Ayurveda), M.S. Regional Ayurveda Research Institute for Endocrine Disorders, Jaipur, Rajasthan, India 19. Research Officer (Ayurveda), Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneswar, Odisha, India 20. Senior Statistical Assistant (Statistics), Central Council for Research in Ayurvedic Sciences New Delhi, India 21. Statistical Officer (Statistics), Central Council for Research in Ayurvedic Sciences New Delhi, India 22. Deputy Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences New Delhi, India
Abstract
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease which mainly affects the small joints leading to erosion of cartilage and bone associated with irreversible joint damage, joint deformity, and systemic complications. The symptoms of RA resemble with the signs and symptoms mentioned in Amavata described in different texts of Ayurveda. Simhanada Guggulu, Brihat Saindhavadya Taila, Vatari Guggulu, Rasna Saptaka Kashaya, and Hingvashtaka Churna are commonly used in the management of this disease. However, the safety data are not collected on these formulations till now. Objective: Critical analysis and presentation of clinical safety outcomes of classical Ayurvedic formulations Simhanada Guggulu, Brihat Saindhavadya Taila, Vatari Guggulu, Rasna Saptaka Kashaya, and Hingvashtaka Churna in patients of RA generated for Research in Ayurvedic Sciences (CCRAS) centers. Materials and methods: Data were collected from three different clinical studies executed in peripheral institutes of CCRAS and were critically evaluated to assay the safety profile of five formulations. Safety assessments were done through analyzing liver function tests (LFTs) and kidney function tests (KFTs) before and after the study trial period. Conclusion: The findings in the three different clinical studies clearly indicate that Simhanada Guggulu, Brihat Saindhavadya Taila, Vatari Guggulu, Rasna Saptaka Kashaya, and Hingvashtaka Churna are clinically safe and tolerable in the participants belonging to different age groups, gender, geographical area, and different prakrti. Keywords: Amavata, Brihat Saindhavadya Taila, Hingvashtaka Churna, Rasna Saptaka Kashaya, Rheumatoid arthritis, Safety, Simhanada Guggulu, Vatari Guggulu.
DHARA ID: D059562
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