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Journal of Research in Ayurvedic Sciences 2017 April - June ; 1 (2) :90-98
Clinical Efficacy of Ayurvedic Formulations Rajahpravartini Vati, Varunadi Kashaya and Kanchanar Guggulu in the Management of Polycystic Ovary Syndrome: A Prospective, Open-label, Multicenter Study

Abstract
Introduction: Polycystic ovary syndrome (PCOS) is characterized by oligo-anovulation, clinical or biochemical hyperandrogenism, and polycystic ovaries. It is a metabolic disorder and around 4 to 9% of women of reproductive age are affected by it. Objective: To evaluate the clinical usefulness of Rajahpravartini Vati, Varunadi Kashaya, and Kanchanar Guggulu in the management of PCOS and changes in the quality of life (QOL) of PCOS women. Materials and methods: It was a multicenter single-arm prospective study. Sixty women aged between 18 and 40 years with PCOS confirmed as per Rotterdam criteria 2003, i.e., hyperandrogenism clinically (hirsutism)/or biochemically (elevated serum testosterone concentrations), anovulation/ or oligomenorrhea, or amenorrhea after negative screening pregnancy test and/or polycystic ovary were included in the study. Ayurvedic regimen comprising Rajahpravartini Vati (250 mg), Kanchanar Guggulu (500 mg), and Varunadi Kashaya (20 mL) was administered with lukewarm water twice daily for 180 days. The outcome measures were attainment of normal menstrual cycle length, changes on acne score, hirsutism (Ferriman–Gallwey score), and improvement in QOL of women with PCOS. Results: The trial drugs have statistically significant effect (p<0.001) on the signs and symptoms, i.e., oligomenorrhea,presence of body hair. The drugs have significant effects on reducing the number of cysts in both the ovaries (p-value<0.001) and also improvement in QOL of the women studied. There was no adverse event reported during the study period and all laboratory safety parameters were within the normal range. Conclusion: Rajahpravartini Vati, Varunadi Kashaya, and Kanchanar Guggulu have shown a positive role for the treatment of PCOS and to improve the QOL of the subjects and clinically safe to use. Keywords: Kanchanar Guggulu, Menstrual cycle, Polycystic ovary syndrome, Quality of life, Rajahpravartini Vati, Varunadi Kashaya

DHARA ID: D059559


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