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Journal of Research in Ayurvedic Sciences 2017 April - June ; 1 (2) :81-89
Clinical Efficacy and Safety of Chyavanaprasha on Aging in Apparently Healthy Elderly Subjects: A Prospective, Open-label, Multicenter Study
Pitta Srinivas (1), Pitta Srinivas (1), Sanjaykumar Giri (2), Sanjaykumar Giri (2), Sneha Marlewar (3), Sneha Marlewar (3), K Prameela Devi (4), K Prameela Devi (4), Kishore Kumar (5), Kishore Kumar (5), R Govind Reddy (6), R Govind Reddy (6), Bhagwan Sahai Sharma (3), Bhagwan Sahai Sharma (3), Shruti Khanduri (7), Shruti Khanduri (7), Rakesh Rana (8), Rakesh Rana (8), Richa Singhal (9), Richa Singhal (9), Narayanam Srikanth (10), Narayanam Srikanth (10)
1. Research Officer (Ayurveda), Dr. Achanta Lakshmipathi Research Centre for Ayurveda Chennai, Tamil Nadu, India 2. Research Officer (Ayurveda), Regional Ayurveda Research Institute for Metabolic Disorders Bengaluru, Karnataka, India 3. Research Officer (Ayurveda), Central Ayurveda Research Institute for Cancer, Mumbai Maharashtra, India 4. Dr. Achanta Lakshmipathi Research Centre for Ayurveda Chennai, Tamil Nadu, India 5. Research Officer (Ayurveda), 6Central Ayurveda Research Institute for Cancer, Mumbai Maharashtra, India 6. Research Officer (Ayurveda),Central Ayurveda Research Institute for Cancer, Mumbai Maharashtra, India 7. Research Officer (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India 8. Statistical Officer (Statistics), Central Council for Research in Ayurvedic Sciences, New Delhi, India 9. Senior Statistical Assistant (Statistics), Central Council for Research in Ayurvedic Sciences, New Delhi, India 10. Deputy Director General (Ayurveda), Central Council for Research in Ayurvedic Sciences, New Delhi, India
Abstract
Introduction: Aging is a persistent decline in an individual’s physiological and structural attributes with time, and geriatric care has become a top specialty. Ayurveda has suggested regimes for graceful aging and it is included under the spectrum of Rasayana therapy. Chyavanaprasha is a preparation that has been mentioned in the classics as an excellent rejuvenator with ability to delay aging and enhance general wellbeing. Objective: To evaluate the efficacy and safety of Chyavanaprasha in improving general body health and quality of life (QOL) in apparently healthy elderly subjects. Materials and methods: A prospective open-label multiple center clinical study was carried out at three peripheral centers of the Central Council for Research in Ayurvedic Sciences and 214 subjects satisfying the selection criteria were enrolled and were administered Chyavanaprasha Lehyam 12 gm twice daily before food with milk for 12 weeks and the effect of the drug was assessed at intervals of 14 days up to 84 days. Paired sample t-test was used to compare mean change in functional exercise capacity by 6 minutes walk test (MWT) and changes in QOL using World Health Organization (WHO) QOL BREF scale from baseline to the 84th day. A p-value of <0.05 was considered significant. Results: Statistically significant improvement was observed in WHO QOL BREF score (p-value <0.001) and functional exercise capacity: Blood sugar, serum cholesterol, kidney function test, and liver function test (LFT) were within normal limits during the entire trial. No adverse drug reaction or adverse event was reported during the trial period.Conclusion: Chyavanaprasha administered in the abovementioned dose was found effective and safe in apparently healthy elderly subjects in improving their QOL. Keywords: Aging, Chyavanaprasha, Quality of life, Rasayana, Six minutes walk test
DHARA ID: D059558
Link To Full Paper

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