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Ancient Science of Life
2017
April - June
;
36
(4)
:207-214
Chemical characterization of an Ayurvedic herbo-mineral formulation - Vasantakusumakara Rasa: A potential tool for quality assurance
Sarada Ota (1)
,
Sarada Ota (1)
,
Arjun Singh (2)
,
Arjun Singh (2)
,
Narayana Srikanth (3)
,
Narayana Srikanth (3)
,
Bojja Sreedhar (4)
,
Bojja Sreedhar (4)
,
Kartar Singh Dhiman (4)
,
Kartar Singh Dhiman (4)
,
Galib Ruknuddin (5)
,
Galib Ruknuddin (5)
1. Department of Ayurveda (Parsuti Tantra and Stri Roga), Central Council for Research in Ayurvedic Sciences, Hyderabad, Telangana, India 2. Department of Chemistry, Central Council for Research in Ayurvedic Sciences, Hyderabad, Telangana, India 3. Department of Ayurveda (Shalakya Tantra), Central Council for Research in Ayurvedic Sciences, Hyderabad, Telangana, India 4. Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology (CSIR), Hyderabad, Telangana, India 5. Department of Ras Shastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, India
Abstract
Background: Herbo-mineral formulations of Ayurveda contain specified metals or minerals as composition, which have their beneficial effects on biological systems. These metals or minerals are transformed into non-toxic forms through meticulous procedures explained in Ayurveda. Though literature is available on quality aspects of such herbo-mineral formulations; contemporary science is raising concerns at regular intervals on such formulations. Thus, it becomes mandate to develop quality profiles of all formulations that contain metals or minerals in their composition. Considering this, it is planned to evaluate analytical profile of Vasantakusumakara Rasa. Objective: To prepare Vasantakusumakara Rasa as per Standard operating Procedures (SoP) mentioned in classical text and to characterize it chemically using modern analytical techniques. Materials and Methods: The drug (Vasantakusumakara Rasa) in three batches was prepared in GMP certified pharmacy. Physico-chemical analysis, Assay of elements and HPTLC were carried out as per API. XRD was conducted using Rigaku Ultima-IV X-ray diffractometer. Results: The analysis shown the presence of Mercury, Tin, Gold, Silver, Iron, Zinc and Calcium etc., and HPTLC revealed presence of organic constituents from plant material. The XRD indicated the presence of cinnabar (mercury sulphide from Rasa Sindhura), cassiterite (tin oxide from Va?ga Bhasma), massicot (lead oxide from Naga bhasma) and Magnetite (di-iron oxide from Loha bhasma). Conclusion: The physico chemical analysis reveals that VKR prepared by following classical guidelines is very effective in converting the macro elements into therapeutically effective medicines in micro form. Well prepared herbo-mineral drugs offer many advantages over plant medicines due to their longer shelf life, lesser doses, easy storing facilities, better palatability etc. The inferences and the standards laid down in this study certainly can be utilized as baseline data of standardization and QC. Keywords: Lead, mercury, Rasa Sindhura, Vasantakusumakara Rasa, X-ray diffraction
DHARA ID:
D059370
Pubmed ID:
29269973
Link To Full Paper
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