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Complementary Therapies in Clinical Practice 2022 Aug ; 48 :101601 [Epub ahead of Print]
Efficacy of add-on Ayurveda and Yoga intervention in health care workers of tertiary care hospital during COVID-19: Randomized controlled trial
Vandna Sharma (1), Vandna Sharma (1), Bharat Krushna Khuntia (2), Bharat Krushna Khuntia (2), Manish Soneja (3), Manish Soneja (3), Vitthal G Huddar (4), Vitthal G Huddar (4), S Ramakrishnan (5), S Ramakrishnan (5), Payal Sharma (6), Payal Sharma (6), Shubhangi Rathore (7), Shubhangi Rathore (7), Varun Valliappan (8), Varun Valliappan (8), Mohit Wadhawan (9), Mohit Wadhawan (9), Varun Chhabra (10), Varun Chhabra (10), Aman Agarwal (11), Aman Agarwal (11), Mansingh Jat (12), Mansingh Jat (12), Arvind Kumar (13), Arvind Kumar (13), Tanuja Manoj Nesari (14), Tanuja Manoj Nesari (14), Gautam Sharma (15), Gautam Sharma (15)
1. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: vandnasharma25@gmail.com 2. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: aurobharat@gmail.com 3. Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: manishsoneja@gmail.com. 4. Department of Kayachikitsa (Internal Medicine), All India Institute of Ayurveda, New Delhi, 110076, India. Electronic address: dr.vghuddar@aiia.gov.in. 5. Department of Cardiology, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: ramaaiims@gmail.com 6. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: payalsharma204@gmail.com. 7. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: drshubhangi.rathore@gmail.com. 8. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: drvarun30@gmail.com 9. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: mohit.wadhawan@yahoo.com. 10. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: varunchhabra0@gmail.com 11. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: amanstatistician01@gmail.com. 12. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: mansingh.aiims@gmail.com. 13. Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: linktoarvind@gmail.com. 14. Department of Dravyaguna (Materia Medica & Pharmacology), All India Institute of Ayurveda, New Delhi, 110076, India. Electronic address: tnesari@hotmail.com. 15. Centre for Integrative Medicine and Research (CIMR), All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. Electronic address: drgautamsharma12@gmail.com.
Abstract
Background: The present study aimed to evaluate the safety and prophylactic efficacy of add-on Comprehensive Ayurveda and mindfulness-based Yoga (CAY) regimen to standard care among HealthCare Workers (HCWs) against COVID-19. Materials and methods: This prospective single-blind (outcome assessor-blinded) RCT was conducted in tertiary care hospital in Delhi during July 2020-April 2021. HCWs of both sexes were randomized to add-on CAY intervention or control group. The primary outcomes were the incidence of confirmed COVID-19 positive cases and influenza-like illness events (ILI). Secondary outcomes were anxiety (GAD-7), depression (PHQ-9), and quality of life (SF-36) at the end of 12 weeks. Results: Three hundred fifty-six participants (181 in intervention and 175 in the control group) were randomized. With the modified intention to treat approach, we analyzed 309 participants. The mean age for the intervention and control group was 39.3 ± 10.1 and 36.6 ± 10 years, respectively. Incidence of COVID-19 event was higher in control group compared to CAY group (16 of 164 [9.8%] vs. 11 of 145 [7.6%]; P = 0.50). The incidence of ILI events was also higher in the control group as compared to the CAY group (14 of 164 [8.5%] vs 9 of 145 [6.2%]). The health change domain of the SF-36 questionnaire showed statistically significant improvement in the CAY group as compared to the control group (P < 0.01). Conclusion: Incidence of COVID-19 and ILI events was lower in the CAY group compared with the contr ol group, though the difference is not statistically significant. Keywords: Anxiety; Ayurveda; COVID-19; Complementary therapy; RCT; Yoga.
DHARA ID: D059287 Pubmed ID: 35598547
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