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Ayu 2008 October ; 29 (4) :230-233
A comparative study on Vrikka Samrakshanatmaka and Ashmarighna effect of Tiladi Kshara and Varunadi Ghrita (Nephroprotective and Lithotripsic effect)

Abstract
The kidneys play a very important role in the maintenance of homeostasis in the body. They perform several important functions like normal fluid and acid base balance, electrolyte balance, production and secretion of hormones and excretion of metabolic products. Kidneys are highly vascularized organs recieving around 20-25% of the cardiac output, because of this reason they are constantly exposed to xenobiotics including environmental pollutants, and hence are on the risk of nephrotoxicity. In Ayurveda several drugs are used as nephroprotectives, in this study the well known Ayurvedic compound formulations' Varunadi Ghrita' and Tiladi Kshara were used to evaluate the nephroprotective effect against gentamycin induced nephrotoxicity. Total 36 animals in 6 groups were taken and weighed. Test drugs and vehicles were administered to respective groups, after 2 hours, Gentamycin (60mg/kg. I.P.)was administered to all groups except water control group for 15consecutive days. The 16th day animals were eighed once again and sacrificed by cervical dislocation and severing the jugular veins. Blood samples and kidneys were collected for estimation of serum biochemical investigations and histopathological studies respectively.Accuratelly weighed kidney tissues were also taken and homogenate was prepared for this estimation of different biochemical investigations.the result in the context of the objective of the study emerges that Varunadi Ghrita possess moderate nephroprotective activity. However, the study could not provide basis for its relevance to the probable efficacy of the tst drug in kidney stone induced nephropathy.

DHARA ID: D000308


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