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Ayu 2007 July ; 28 (3) :68-76
A comparative Psycho-Neuro-Pharmacological study on Guduchyadi Ghrita & Bhringarajadi Ghrita rasayana

Abstract
This study has been carried out to compare the psycho-neuro-pharmacological basis for the use of Guduchyadi Ghrita and Bhringarajadi Ghrita. Guduchyadi Ghrita Rasayana consisting of Guduchi (Tinospora cordifolia Linn), Apamarga (Achyrethus aspera Linn), Vidanga (Embelia ribes Burm F.), Shankhapushpi (Convolvulus pluricaulis Chois), Vacha (Acorus calamus Linn), Haritaki (Terminalia chebula retz), Kushta (Saussurea lappa C.B.Clarke) and Shatavari (Asparagus racemosus Willd), has proven mental health promoting, memory enhacing, anti stress, anti depressant properties that may slow down the aging proces by counteracting stress. Bhringarajadi Rasayana consisting of Bhringaraja (Eclipta alba Hassk.), Krishna Tila (Sesamum orientale Linn), Amalaki (Emblica officinalis Gaertn.), Mishri (sugar) with proven adaptogenic, antioxidant, free radicals scavenger, immuno-modulator properties play a major role in the management of aging process. Both the formulations are supposed to possess CNS activity, anti stress, adaptogenic and other pharmacological activities. Based on this promise thr test ghrita has been studied on various experimental models such as gross behaviour test, anti depressant test, anti anxiety test and anti stress adaptogenic test on swiss albino mice and charles foster strain albino rats of either sex. On gross behaviour study, both the test drugs showed hypoactivity. In the anti depressant activity, Guduchyadi Ghrita showed significant decrease in the mice behavioral 'despair' test, moderate decrease in mice immobilityin chronic fatigue syndrome test and produced potentiation of L dopa effects. Bhringarajadi Ghrita showed no discernible anti depressant and chronic fatigue sndrome test though moderate potentiation of L dopa effect was observed. Guduchyadi Ghrita also produces antianxiety activity and adaptogenic activity. None of the formulation was able to reverse stress induced Hypothermia. Slightly higher decrease in stress induced ulceration was observed with Guduchyadi Ghrita, however Bhringarajadi Ghrita had no effect. No statistically significant effect observed on haemetological, biochemical parameter and DHEA-S. Guduchyadi Ghrita showed marginal elevation of Dhea-S (Dehydroepiandrosterone Sulfate) level.

DHARA ID: D000272


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