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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Saudi journal of biological sciences
2017
May
;
(4)
:0
Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent.
Rajakrishnan R R (1)
,
Lekshmi R R (2)
,
Benil P B PB (3)
,
Thomas J J (1)
,
AlFarhan A H AH (1)
,
Rakesh V V (1)
,
Khalaf S S (1)
1. Dept. of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, Saudi Arabia. 2. Dept. of Botany and Biotechnology, MSM College, Kayamkulam, Kerala, India. 3. Dept. of Agadatantra, Vaidyaratnam P.S Varier Ayurveda College, Edarikode P.O., Kottakkal, Kerala, India.
Abstract
Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protective effect of hydroalcoholic extract of P. zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect. The antioxidant effect of the drug is evident from its significant effect on Catalase, Glutathione peroxidase and lipid peroxidation activities.
DHARA ID:
D056252
Pubmed ID:
28490944
Access to Full Paper Not Available
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