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Pharmaceutical Biology
2017
Dec
;
(1)
:0
Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats.
Dey Yadu Nandan YN c Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University , Meerut , Uttar Pradesh , India. (1)
,
Sharma Garima G (2)
,
Wanjari Manish M MM (1)
,
Kumar Dharmendra D e Faculty of Pharmaceutical Sciences, UCSI University , Kaula Lumpur , Malaysia. (3)
,
Lomash Vinay V (4)
,
Jadhav Ankush D AD (1)
1. a National Research Institute for Ayurveda-Siddha Human Resource Development , Gwalior , Madhya Pradesh , India , (Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, New Delhi, India). 2. b School of Studies in Biomedical Technology, Jiwaji University , Gwalior , Madhya Pradesh , India. 3. c Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University , Meerut , Uttar Pradesh , India. 4. d Shriram Institute for Industrial Research , New Delhi , India.
Abstract
The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders.The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats.Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500?mg/kg) or standard drug, prednisolone (PRDS) (4?mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48?h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon.APME or APAE pretreatment significantly (p?
DHARA ID:
D056073
Pubmed ID:
27600166
Access to Full Paper Not Available
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