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Pharmaceutical Biology 2017 Dec ; (1) :0
Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism.

Celastrus paniculatus Wild. (Celasteraceae) (CP) is a well-known Ayurvedic 'Medhya Rasayana' (nervine tonic), used extensively as a neuro-protective and memory enhancer, and in different central nervous system disorders.To evaluate the effect of CP against 3-nitropropionic acid (3-NP) induced Huntington's disease (HD) like symptoms in Wistar male rats.The ethanol extract of CP seeds (CPEE), prepared by maceration, was standardized on the basis of linoleic acid content (6.42%) using thin layer chromatography densitometric analysis. Protective effect of CPEE (100 and 200?mg/kg) and its various fractions, viz., petroleum ether (40?mg/kg), ethyl acetate (2.5?mg/kg), n-butanol (7?mg/kg) and aqueous (18?mg/kg), administered orally for 20 days, against 3-NP (10?mg/kg, i.p. for 14 days) was assessed by their effect on body weight, locomotor activity, grip strength, gait pattern and cognitive dysfunction and biochemical parameters for oxidative damage in the striatum and cortex regions of the brain.CPEE (100 and 200?mg/kg) treated animals exhibited a significant (p?

DHARA ID: D056049 Pubmed ID: 28164735

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