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Pharmaceutical Biology 2015 Oct ; (10) :0
Protective effect of Convolvulus pluricaulis standardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats.

Abstract
Convolvulus pluricaulis Chois. (Convolvulaceae), a well-known Ayurvedic "Medhya Rasayana" (nervine tonic), is extensively used for different central nervous system (CNS) disorders.The objective of this study was to evaluate the protective effect of standardized hydro-methanol extract of C. pluricaulis (CPE) and its fractions, namely ethyl acetate (EAE), butanol (BE), and aqueous (AE), against 3-nitropropionic acid (3-NP) induced neurotoxicity in rats.The extract of the whole plant was standardized on the basis of scopoletin content (0.014%) using thin layer chromatography densitometric analysis. CPE (100 and 200?mg/kg) and its fractions, namely EAE (15 and 30?mg/kg), BE (25 and 50?mg/kg), and AE (50 and 100?mg/kg) were administered orally for 20?d. Their protective effect against 3-NP (10?mg/kg, i.p. for 14?d) was assessed by the effect on various behavioral parameters, namely body weight, locomotor activity, grip strength, gait pattern, and the effect on cognitive dysfunction. Biochemical parameters for oxidative damage were also assessed in the striatum and cortex regions of the brain.Administration of 3-NP induced HD-like symptoms that were indicated by reduced body weight, locomotor activity, memory, grip strength, and oxidative defense. CPE (200?mg/kg), EAE (30?mg/kg), and BE (50?mg/kg) significantly (p?

DHARA ID: D055614 Pubmed ID: 25853968


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