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Bioscience, biotechnology, and biochemistry 2006 Nov ; (11) :0
An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius.

Abstract
The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml).

DHARA ID: D051285 Pubmed ID: 17090940


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