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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Natural Products
2005
Jun
;
(6)
:0
Indole alkaloids and other constituents of Rauwolfia serpentina.
Itoh A
,
Kumashiro T
,
Yamaguchi M
,
Nagakura N
,
Mizushina Y
,
Nishi T
,
Tanahashi T
Abstract
From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N(b)-methylajmaline (1), N(b)-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.
DHARA ID:
D047997
Pubmed ID:
15974606
Access to Full Paper Not Available
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