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Planta Medica 2001 Dec ; (9) :0
Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa.
Song EK,   Cho H,   Kim JS,   Kim NY,   An NH,   Kim JA,   Lee SH,   Kim YC  

Abstract
Assay-guided fractionation of the EtOAc soluble fraction of the rhizomes of Curcuma longa furnished three DPPH free radical scavenging diarylheptanoids, curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3). Compounds 1-3 showed the DPPH radical scavenging effects with IC(50) values of 2.8, 39.2, 308.7 microM, respectively. L-Ascorbic acid and resveratrol as positive controls exhibited IC(50) values of 22.5 and 25.0 microM, respectively. Compounds 1-3 showed significant hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of 1-3 are 86.9, 70.7, and 50.2 microM, respectively. Silybin (EC(50) = 69.0 microM) and silychristin (EC(50) = 82.7 microM) were used as positive controls.

DHARA ID: D046635 Pubmed ID: 11745031


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