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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Biological & pharmaceutical bulletin
2005
May
;
(5)
:0
Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.
Kuroda M
,
Mimaki Y
,
Nishiyama T
,
Mae T
,
Kishida H
,
Tsukagawa M
,
Takahashi K
,
Kawada T
,
Nakagawa K
,
Kitahara M
Abstract
The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A(y) mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-gamma ligand-binding activity in a GAL4-PPAR-gamma chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-gamma ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-gamma activation.
DHARA ID:
D046519
Pubmed ID:
15863912
Access to Full Paper Not Available
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