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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Ethnopharmacology
2004
Sep
;
(1)
:0
Effect of garlic (Allium sativum) on lipid peroxidation in experimental myocardial infarction in rats.
Saravanan G
,
Prakash J
Abstract
The present study was conducted to elucidate the antioxidant role of garlic oil in isoproterenol (IPL)-induced myocardial infarction in rats. In myocardial necrosis induced by isoproterenol, a significant increase in serum iron content with a significant decrease in plasma iron binding capacity, ceruloplasmin activity and glutathione (GSH) level were observed. There was also a significant increase in lipid peroxides levels on isoproterenol administration. Activities of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST) and glutathione reductase (GRD) were decreased significantly in heart with isoproterenol-induced myocardial necrosis. Garlic oil produced a marked reversal of these metabolic changes related to myocardial infarction induced by isoproterenol. In conclusion, garlic oil exerts its effects by modulating lipid peroxidation and enhancing antioxidant and detoxifying enzyme systems.
DHARA ID:
D044197
Pubmed ID:
15261977
Access to Full Paper Not Available
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