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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Biological & pharmaceutical bulletin
1994
Nov
;
(11)
:0
Cardiotonic flavonoids from Citrus plants (Rutaceae).
Itoigawa M
,
Takeya K
,
Furukawa H
Abstract
Two flavonoids, 3,5,6,7,8,3',4'-heptamethoxyflavone (HEPTA) and natsudaidain isolated from Citrus plants (Rutaceae), produced a positive inotropic effect (PIE) on guinea-pig papillary muscle. Natsudaidain (pD2 4.98 +/- 0.07) was more potent than HEPTA (pD2 4.33 +/- 0.08), but the maximum PIE of HEPTA was greater than that of natsudaidain. The PIE of HEPTA was completely inhibited by reserpinization of the guinea pig, and partially inhibited by metoprolol and carbachol. The carbachol inhibition was omitted by atropine. The mechanism of PIE of HEPTA is accounted for catecholamine release from cardiac tissue.
DHARA ID:
D042487
Pubmed ID:
7703977
Access to Full Paper Not Available
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