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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Natural Products
2004
Nov
;
(11)
:0
Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
Okuno Y
,
Miyazawa M
Abstract
Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.
DHARA ID:
D040900
Pubmed ID:
15568779
Access to Full Paper Not Available
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