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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Planta Medica
2005
Jan
;
(1)
:0
Antitumor-promoting activity of coumarins from citrus plants.
Ito C
,
Itoigawa M
,
Ju-ichi M
,
Sakamoto N
,
Tokuda H
,
Nishino H
,
Furukawa H
Abstract
In order to identify antitumor-promoting agents, we performed primary in vitro screening of 31 coumarins isolated from 11 plants of the Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of the 8-substituted coumarins, 8-formyl-7-hydroxycoumarin (5), osthenol (7), demethylauraptenol (8), osthenon (9) and dihydroosthenon (10), were found to significantly inhibit EBV-EA activation (IC50: 129-207 mol ratio/32 pmol TPA). Osthenol (7) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
DHARA ID:
D040852
Pubmed ID:
15678381
Access to Full Paper Not Available
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