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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Chemistry & Biodiversity
2009
Mar
;
(3)
:0
Nematicidal cardenolides from Nerium indicum Mill.
Wang XB
,
Li GH
,
Zheng LJ
,
Ji KY
,
Lü H
,
Liu FF
,
Dang LZ
,
Mo MH
,
Zhang KQ
Abstract
Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation. They include a new compound, 3beta-O-(beta-D-diginosyl)-14,15alpha-dihydroxy-5alpha-card-20(22)-enolide (1), and two known compounds, uzarigenin (2) and cardenolide N-1 (3). The median lethal concentrations (LC(50)) of compounds 1-3 against the nematodes Bursaphelenchus xylophilus, Panagrellus redivivus, and Caenorhabditis elegans at 72 h were 103.3, 49.0, and 45.4 mg l(-1), 257.0, 62.7, and 177.8 mg l(-1), and 242.9, 29.1, and 41.7 mg l(-1), respectively. This is the first report about the nematicidal activity of cardenolides.
DHARA ID:
D037212
Pubmed ID:
19319871
Access to Full Paper Not Available
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