Home | About | Quick Start | FAQ
Beta Version 0.1
DHARA is an online index of articles on Ayurveda published in research journals worldwide. Users Online: 701
  Enter Keyword Below :
      
Advanced

Bioscience, biotechnology, and biochemistry 2008 Feb ; (2) :0
Isolation of apoptosis- and differentiation-inducing substances toward human promyelocytic leukemia HL-60 cells from leaves of Juniperus taxifolia.

Abstract
A chloroform extract of the leaves of Juniperas taxifolia exhibited a marked antiproliferative effect on human promyelocytic leukemia HL-60 cells at a concentration of 2.5 microg/ml. Deoxypodophyllotoxin (4) was identified in the extract as an outstanding antiproliferative compound, and five diterpenes (1-3, 5, and 6) were isolated as known compounds with weak or no cytotoxicity. These compounds were examined for their respective apoptosis- and differentiation-inducing activities toward HL-60 cells by DNA fragmentation and NBT-reducing assays, respectively. Among them, 7alpha-hydroxysandaracopimaric acid (6) was found to have a potent differentiation-inducing activity in a dose-dependent manner at 0.125-2 microg/ml (0.39-6.29 microM), together with apoptosis-inducing activity at concentrations of more than 2.5 microg/ml (7.86 microM). Deoxypodophyllotoxin (4) that exerted cytotoxic and apoptosis-inducing activities at 2 ng/ml (5 nM) did not induce differentiation at the same concentration, and the other diterpenes (1-3 and 5) showed no effect on cell differentiation, even at 5 microg/ml. It was thus demonstrated for the first time that 7alpha-hydroxysandaracopimaric acid was an effective differentiation-inducing compound toward HL-60 cells.

DHARA ID: D037025 Pubmed ID: 18256464


Access to Full Paper Not Available

Replica Louis vuitton Belts Replica Louis vuitton Handbags Replica Louis vuitton Backpack Replica Louis vuitton Capucines Bags Imitazioni Louis vuitton Borse Imitazioni Louis vuitton Cinture Imitazioni Louis vuitton Occhiali Replica Louis vuitton Geldb?rsen Replica Louis vuitton Gürtel Replica Louis vuitton Schmuck Replica Louis vuitton Schal Imitation Louis vuitton Bijoux Imitation Louis vuitton Ceinture Imitation Louis vuitton Chaussures Imitation Louis vuitton Foulard namaak Louis vuitton Gordels namaak Louis vuitton Handtassen namaak Louis vuitton Portemonnees namaak Louis vuitton Schoenen Replica Louis vuitton Bolsos Replica Louis vuitton Billeteras Replica Louis vuitton Cinturones Dior Replica Hermès Replica Yves Saint Laurent Replica Goyard Replica Imitation Louis Vuitton Imitation Hermès Imitation Dior Imitation Yves Saint Laurent Imitazioni Bottega Veneta Borse Imitazioni Delvaux Borse Imitazioni Goyard Borse Replica Taschen Replica Louis Vuitton Replica Hermès Replica Dior Replica Bottega Veneta tassen Replica Chloé tassen Replica Delvaux tassen Replica Goyard tassen imitacion Louis Vuitton imitacion Louis Vuitton imitacion Hermès imitacion Dior Replica Miu Miu Replica Prada Replica Yves Saint Laurent Replica Chanel Replica Gucci Replica Hermès Replica Miu Miu Réplique Chanel Réplique Hermès Réplique Miu Miu Imitazioni Chanel Imitazioni Hermès Imitazioni Miu Miu imitacion Bolso Yves Saint Laurent imitacion Hermes imitacion Chanel imitacion Gucci Gucci Replica Hermes Replica

Copyright | Disclaimer | Feedback | Updates | Contact
Developed and maintained by AVP Research Foundation (Formerly AVT Institute for Advanced Research), 136/137, Trichy Road, Ramanathapuram, Coimbatore - 641045, Tamil Nadu, India
Funded by Central Council for Research in Ayurvedic Sciences, Dept. of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi