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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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International Journal of Molecular Medicine
2003
Nov
;
(5)
:0
Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: multi-center open trial.
Kanauchi O
,
Mitsuyama K
,
Homma T
,
Takahama K
,
Fujiyama Y
,
Andoh A
,
Araki Y
,
Suga T
,
Hibi T
,
Naganuma M
,
Asakura H
,
Nakano H
,
Shimoyama T
,
Hida N
,
Haruma K
,
Koga H
,
Sata M
,
Tomiyasu N
,
Toyonaga A
,
Fukuda M
,
Kojima A
,
Bamba T
Abstract
Germinated barley foodstuff (GBF), which mainly consists of dietary fiber and glutamine-rich protein, is a prebiotic for ulcerative colitis (UC). In our previous study, we carried out a clinical trial of GBF with mildly to moderately active UC patients and showed that GBF treatment was able to attenuate the symptoms of UC in a relatively short-term. The aim of this study was to investigate the efficacy of long-term administration of GBF in the treatment of UC in a multi-center open trial. Twenty-one patients with mildly to moderately active UC received 20-30 g of GBF for 24 weeks in an open-label protocol while baseline treatments (5-amino-salicyrate compounds and/or steroids) were continued. The response to the GBF treatment was evaluated using a clinical scoring and after 24 weeks of observation, the GBF group showed a significant decrease in clinical activity index (especially, the degree of visible blood in stools and the presence of nocturnal diarrhea) compared with the control group (p<0.05). No side effects related to GBF were observed. In conclusion, GBF can reduce the clinical activity of UC over long-term as well as short-term administration. Nutraceutical GBF therapy may have a place in long-term management of UC, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder.
DHARA ID:
D033812
Pubmed ID:
14532996
Access to Full Paper Not Available
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