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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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International Journal of Molecular Medicine
1998
Oct
;
(4)
:0
Germinated barley foodstuff increases fecal volume and butyrate production at relatively low doses and relieves constipation in humans.
Kanauchi O
,
Mitsuyama K
,
Saiki T
,
Nakamura T
,
Hitomi Y
,
Bamba T
,
Araki Y
,
Fujiyama Y
Abstract
Germinated barley foodstuff (GBF), derived from the aleurone layer, scutellum and germ of germinated barley, contains a large quantity of fermentable dietary fibers, especially hemicellulose. GBF was given to 9 healthy volunteers in a dose of 9 g of GBF per day for 10 consecutive days, and subsequently 18 g of GBF for another 10 days. As a control, no GBF was given for 3 days before administration of GBF (control period). Fecal weight, water content and short chain fatty acid content were measured before and during the last 3 days of each experimental period. Feeding of GBF significantly increased the fecal butyrate content as well as fecal weight at both dose-levels (9 and 18 g/day), compared with those during the control period. Daily administration of 9 g GBF induced the maximum level of defecation in humans. Relatively mild but chronic constipated volunteers (n = 16) were administered 9 g of GBF daily for 14 days. In this experiment, the condition of defecation (frequency, volume) was estimated by a questionnaire survey. GBF significantly improved defecation within a short period without severe adverse effects. No major abnormalities in laboratory findings were found in hematologic and urinary analyses. In conclusion, daily administration of 9 g GBF was effective for improving defecation in healthy but constipated humans. GBF is a highly safe and effective foodstuff for improving defecation.
DHARA ID:
D032365
Pubmed ID:
9857232
Access to Full Paper Not Available
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