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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Alimentary pharmacology & therapeutics
1998
Dec
;
(12)
:0
Treatment of ulcerative colitis with germinated barley foodstuff feeding: a pilot study.
Mitsuyama K
,
Saiki T
,
Kanauchi O
,
Iwanaga T
,
Tomiyasu N
,
Nishiyama T
,
Tateishi H
,
Shirachi A
,
Ide M
,
Suzuki A
,
Noguchi K
,
Ikeda H
,
Toyonaga A
,
Sata M
Abstract
Germinated barley foodstuff (GBF) has been shown to attenuate intestinal injury in animal models, largely by increasing luminal short-chain fatty acid production.To investigate the safety and efficacy of GBF in the treatment of ulcerative colitis (UC).Ten patients with active UC received 30 g of GBF daily for 4 weeks in an open-label treatment protocol while the baseline anti-inflammatory therapy was continued. The response to treatment was evaluated clinically and endoscopically. Pre- and post-treatment stool concentrations of short-chain fatty acids were measured by gas-liquid chromatography.Patients showed improvement in their clinical activity index scores, with a significant decrease in the score from 6.9+/-1.4 to 2.8+/-1.5 (mean+/-S.E.M., P < 0.05). The endoscopic index score fell from 6.1+/-2.3 to 3.8+/-2.3 (P < 0.0001). Patients showed an increase in stool butyrate concentrations after GBF treatment (P < 0.05). No side-effects were observed.Oral GBF therapy may have a place in management of ulcerative colitis, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder.
DHARA ID:
D032352
Pubmed ID:
9882030
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