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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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2006
May
;
(13)
:0
A transgenic rice seed accumulating an anti-hypertensive peptide reduces the blood pressure of spontaneously hypertensive rats.
Yang L
,
Tada Y
,
Yamamoto MP
,
Zhao H
,
Yoshikawa M
,
Takaiwa F
Abstract
RPLKPW is a potent anti-hypertensive peptide designed according to the structure of ovokinin(2-7) (RADHPF). In this study, we generated transgenic rice plants that accumulate the RPLKPW peptide as a fusion protein with the rice storage protein glutelin. The engineered peptide is expressed under the control of endosperm-specific glutelin promoters and specifically accumulates in seeds. Oral administration of either the RPLKPW-glutelin fraction or transgenic rice seeds to spontaneously hypertensive rats (SHRs) significantly reduced systolic blood pressures. These results suggest the possible application of transgenic rice seed as a nutraceutical delivery system and specifically for administration of active peptides in hypertension.
DHARA ID:
D021754
Pubmed ID:
16697378
Access to Full Paper Not Available
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