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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Biological & pharmaceutical bulletin
2004
Oct
;
(10)
:0
Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents.
Matsuda H
,
Kawaguchi Y
,
Yamazaki M
,
Hirata N
,
Naruto S
,
Asanuma Y
,
Kaihatsu T
,
Kubo M
Abstract
A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (-)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation.
DHARA ID:
D015166
Pubmed ID:
15467205
Access to Full Paper Not Available
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