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Phytochemistry 2007 Mar ; (6) :0
ACAT inhibition of alkamides identified in the fruits of Piper nigrum.
Rho MC,   Lee SW,   Park HR,   Choi JH,   Kang JY,   Kim K,   Lee HS,   Kim YK  

Abstract
In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated. Their structures were elucidated via spectroscopic analysis ((1)H, (13)C NMR and ESI-MS), as follows: retrofractamide A (1), pipercide (2), piperchabamide D (3), pellitorin (4), dehydroretrofractamide C (5) and dehydropipernonaline (6). The IC(50) values determined for the compounds were 24.5 (1), 3.7 (2), 13.5 (3), 40.5 (4), 60 (5) and 90 microM (6), according to the results of an ACAT enzyme assay system using rat liver microsomes. These compounds all inhibited cholesterol esterification in HepG2 cells.

DHARA ID: D015020 Pubmed ID: 17188313


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