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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Bioorganic & medicinal chemistry
2008
Mar
;
(6)
:0
Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.
Mula S
,
Banerjee D
,
Patro BS
,
Bhattacharya S
,
Barik A
,
Bandyopadhyay SK
,
Chattopadhyay S
Abstract
The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with (1)O(2), as revealed from the rate constant values of (1)O(2) quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating (1)O(2) generated from certain endogenous photosensitizers.
DHARA ID:
D014953
Pubmed ID:
18207412
Access to Full Paper Not Available
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