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Journal of Research in Ayurvedic Sciences 2023 April - June ; 7 (2) :106
An open-label prospective interventional study to assess the prophylactic effect of Guduchi Ghan Vati in COVID-19: A community-based study in containment zone of Himachal Pradesh, India
Kavita Vyas (1), Anubha Chandla (1), Vikas Nariyal (2), Babita Yadav (3), Hetalben D Amin (4), Shruti Khanduri (3), Bhagwan Sahai Sharma (3), Rakesh Kumar Rana (3), Richa Singhal (3), Arunabh Tripathi (3), Bhogavalli Chandrasekhararao (3), Narayanam Srikanth (3), Kartar Singh Dhiman (3)
1. Regional Ayurveda Research Institute, Jaral Pandoh, Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, Mandi, Himachal Pradesh, India 2. Niti Ayoga, Govt. of India, New Delhi, India 3. Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, New Delhi, India 4. Central Ayurveda Research Institute, Kolkata, Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, New Delhi, India
Abstract
BACKGROUND: Several studies have proven the immunomodulatory action of Guduchi (Tinospora cordifolia). Immunomodulation strategy is a crucial requirement to control coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2. Therefore, Guduchi Ghan Vati (GGV), tablets prepared from water extract of T. cordifolia, is selected to prevent COVID-19. OBJECTIVE: This study aimed to know the prophylactic effect of Ayurvedic intervention, that is GGV, in preventing COVID-19 infection among the community of containment areas. MATERIALS AND METHODS: It was an open-label, prospective, nonrandomized, community-based interventional study carried out from May 6 to June 23, 2020, in a containment zone (Bijhari) of District Hamirpur, Himachal Pradesh, India. GGV was given to the community in the dose of 500 mg twice a day with lukewarm water on an empty stomach for 30 days. The demographic and health-related data of the participants were collected using Google forms, and follow-up was done on the 30th day through telephonic interviews. RESULTS: A total of 1165 participants’ data were analyzed to assess the prophylactic effect of GGV. In the sample, 85.2% of participants had no systemic disorders, whereas 13.8% took concomitant medicines for other morbidities. The incidence of COVID-19-positive cases was only 0.1% (n = 01). CONCLUSION: Ayurvedic intervention GGV was found to have prophylactic potential against COVID-19 infection.
DHARA ID: D063941
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