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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Drug Research in Ayurvedic Sciences
2017
October - December
;
2
(4)
:274-280
Evaluation of Antidiabetic Potential of New Dosage Forms of AYUSH 82 in Streptozotocin-induced Type II Diabetic Rats
Manju Setia (1)
,
Manju Setia (1)
,
Arun Gupta (2)
,
Arun Gupta (2)
,
Rajiv K Rai (3)
,
Rajiv K Rai (3)
,
Ankit Nigam (4)
,
Ankit Nigam (4)
,
Narayanam Srikanth (5)
,
Narayanam Srikanth (5)
,
Kartar S Dhiman (6)
,
Kartar S Dhiman (6)
1. Senior Research Scientist, Medical Affairs and Clinical Research Division, Dabur Research and Development Centre, Dabur India Limited Ghaziabad, Uttar Pradesh, India 2. Head, Medical Affairs and Clinical Research Division, Dabur Research and Development Centre, Dabur India Limited Ghaziabad, Uttar Pradesh, India 3. Head, Formulations Division, Dabur Research and Development Centre, Dabur India Limited, Ghaziabad, Uttar Pradesh, India 4. Principal Research Scientist, Dabur Research Foundation, Dabur India Limited, Ghaziabad Uttar Pradesh, India 5. Deputy Director General,Central Council for Research in Ayurvedic Sciences Ministry of AYUSH, New Delhi, India 6. Director General, Central Council for Research in Ayurvedic Sciences Ministry of AYUSH, New Delhi, India
Abstract
Introduction: AYUSH 82 powder is an Ayurvedic antidiabetic formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, Government of India. The antidiabetic potential of AYUSH 82 powder along with its two new dosage forms—AYUSH 82 mixture extract and AYUSH 82 compound extract—has been established to be mediated via a-amylase inhibitory property, insulin-dependent glucose uptake in skeletal muscle cell line (C2C12 myotubes). Aim: In the current study, we investigated the in vivo antidiabetic potential of new dosage forms of AYUSH 82—AYUSH 82 mixture extract and AYUSH 82 mixture extract + Shilajit. Results and conclusion: Oral administration of AYUSH 82 mixture extract for 28 days twice daily could significantly increase serum insulin levels, reduction in Glucose Area under Curve 0 to 90 minutes, fed blood glucose, and triglyceride levels. It also showed improvement in histopathological grading, which resulted in protecting the pancreatic islets from progressive damage. Addition of Shilajit to AYUSH 82 mixture extract did not contribute much improvement in biochemical parameters related to diabetes. Keywords: AYUSH 82 mixture extract, Shilajit streptozotocin, Type II diabetes mellitus
DHARA ID:
D060722
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