Home
|
About
|
Quick Start
|
FAQ
Beta Version 0.1
DHARA is an online index of articles on Ayurveda published in research journals worldwide.
Users Online:
337
Unfiltered
Classified Search
Enter Keyword Below :
Advanced
Inflammopharmacology
2017
May
:0
Terminalia arjuna prevents Interleukin-18-induced atherosclerosis via modulation of NF-?B/PPAR-?-mediated pathway in Apo E-/- mice.
Bhat Owais Mohammad OM (1)
,
Kumar P Uday PU (2)
,
Rao K Rajender KR (3)
,
Ahmad Ashfaq A (1)
,
Dhawan Veena V (4)
1. Department of Pharmcology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. 2. Department of Histopathology, National Institute of Nutrition (NIN), Hyderabad, India. 3. National Centre for Laboratory Animal Sciences (NCLAS), National Institute of Nutrition (NIN), Hyderabad, India. 4. Department of Experimental Medicine and Biotechnology, Research Block-B, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India. veenad2001@yahoo.com.
Abstract
Terminalia arjuna is a medicinal plant well known as a cardiotonic in Ayurvedic system of medicine. We hypothesized that aqueous stem bark extract of T. arjuna (TAE) may inhibit IL-18-induced atherosclerosis via NF-?B/PPAR-?-mediated pathway in Apo E-/- mice.12-week-old, male Apo E-/- mice divided into four groups (n = 6/group) fed with normal chow-diet were employed: GP I: phosphate buffer saline (PBS) (2 month); GP II: rIL-18 (1 month) followed by PBS (1 month); GP III: rIL-18 (1 month) followed by TAE (1 month); GP IV: rIL-18 (1 month) followed by atorvastatin (1 month).IL-18 treatment induced a significant increase (p < 0.001) in pro-inflammatory marker (IL-18) (170 ± 9.16 vs. 1178.66 ± 8.08, pg/ml), and downregulated cholesterol efflux gene (PPAR-?) by ~0.6-fold vs. 1.00 in IL-18-treated mice as compared to the control animals, respectively. TAE treatment to both groups caused a significant reduction in IL-18 to 281.66 ± 9.60 vs. 1178.66 ± 8.08 (pg/ml), upregulated cholesterol efflux gene by ~1.5- vs. 0.6-fold in TAE-treated group, decreased atherogenic lipids, and percentage atherosclerotic lesion area, demonstrating comparable effects with atorvastatin.Our data demonstrate that TAE protects against IL-18-induced atherosclerosis via NF-?B/PPAR-?-mediated pathway.
DHARA ID:
D056126
Pubmed ID:
28547701
Access to Full Paper Not Available
Copyright
|
Disclaimer
|
Feedback
|
Updates
|
Contact
Developed and maintained by AVP Research Foundation (Formerly AVT Institute for Advanced Research), 136/137, Trichy Road, Ramanathapuram, Coimbatore - 641045, Tamil Nadu, India
Funded by Central Council for Research in Ayurvedic Sciences, Dept. of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi