Home
|
About
|
Quick Start
|
FAQ
Beta Version 0.1
DHARA is an online index of articles on Ayurveda published in research journals worldwide.
Users Online:
598
Unfiltered
Classified Search
Enter Keyword Below :
Advanced
Journal of Ethnopharmacology
2016
Nov
:0
Curative effect of Amorphophallus paeoniifolius tuber on experimental hemorrhoids in rats.
Dey Yadu Nandan YN (1)
,
Wanjari Manish M MM (2)
,
Kumar Dharmendra D (3)
,
Lomash Vinay V (4)
,
Jadhav Ankush D AD (5)
1. National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, Madhya Pradesh, India; Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University, Meerut, Uttar Pradesh, India. 2. National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, Madhya Pradesh, India. Electronic address: manish.nriashrd@gmail.com. 3. Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University, Meerut, Uttar Pradesh, India; Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia. 4. Shriram Institute of Industrial Research, New Delhi, India. 5. National Research Institute for Ayurveda-Siddha Human Resource Development, Gwalior, Madhya Pradesh, India.
Abstract
Amorphophallus paeoniifolius (Dennst.) Nicolson (Family- Araceae) is a crop of south East Asian origin. In India, its tuber is widely used in ethnomedicinal practices by different tribes for the treatment of piles (hemorrhoids).The present study evaluated the effect of methanolic and aqueous extract of Amorphophallus paeoniifolius tuber on croton oil induced hemorrhoids in rats.The methanolic extract was standardized with the major phenolic compound, betulinic acid, by HPLC. The hemorrhoids were induced by applying 6% croton oil preparation in the ano-rectal region. Rats were orally administered methanolic and aqueous extract at doses of 250 and 500mg/kg, each for 7 days. Pilex (200mg/kg) was used as reference anti-hemorrhoidal drug. Hemorrhoids were assessed on eighth day by measuring hemorrhoidal and biochemical parameters along with histology of ano-rectal tissue.Croton oil application caused induction of hemorrhoids as indicated by significant (p<0.001) increase in plasma exudation of Evans blue in ano-rectal tissue, macroscopic severity score and ano-rectal coefficient as compared to normal rats. It significantly (p<0.001) elevated lactate dehydrogenase and cytokines (TNF-a and IL-6) levels in serum and increased myeloperoxidase activity and lipid peroxidation in ano-rectal tissue along with marked histological damage as compared to normal rats. Treatment with tuber extracts and pilex significantly (p<0.05-p<0.001) ameliorated Evans blue exudation, hemorrhoidal parameters and other biochemical parameters with attenuation of tissue damage compared to hemorrhoid control rats. The results indicate that tuber extracts exhibited curative action on hemorrhoids. The aqueous extract showed more pronounced effect than methanolic extract. The effects may be attributed to anti-inflammatory and antioxidant properties.Results indicate that tuber of Amorphophallus paeoniifolius exhibited curative action on hemorrhoids through anti-inflammatory and antioxidant properties. The study validates the ethnomedicinal use of tuber in hemorrhoids and implicates its therapeutic potential as an anti-hemorrhoidal agent.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
DHARA ID:
D056107
Pubmed ID:
27426509
Access to Full Paper Not Available
Copyright
|
Disclaimer
|
Feedback
|
Updates
|
Contact
Developed and maintained by AVP Research Foundation (Formerly AVT Institute for Advanced Research), 136/137, Trichy Road, Ramanathapuram, Coimbatore - 641045, Tamil Nadu, India
Funded by Central Council for Research in Ayurvedic Sciences, Dept. of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi