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Journal of cardiovascular pharmacology 2012 Oct :0
Desmodium gangeticum (Linn.) DC. exhibits antihypertrophic effect in isoproterenol-induced cardiomyoblasts via amelioration of oxidative stress and mitochondrial alterations.

Abstract
ABSTRACT:: Cardiac hypertrophy occurs in response to increased workload such as hypertension or valvular heart disease. Oxidative stress has been implicated in cardiac hypertrophy as well as in its transition to heart failure. This study was taken up with the objective to evaluate the role of oxidative stress in cardiomyoblast hypertrophy and its modulation by Desmodium gangeticum which has been traditionally used in Ayurveda, an Indian system of medicine. The methanolic root extract was analyzed for total phenolic content and tested for antioxidant potential. Hypertrophy was induced by exposing H9c2 cell line to ß-adrenergic receptor agonist, isoproterenol for 96 hrs. Analyses of reactive oxygen species generation, mitochondrial transmembrane potential ([INCREMENT]?m) and integrity of permeability transition were performed in isoproterenol as well as Desmodium and isoproterenol cotreated cells. The results demonstrated potent free radical scavenging activity of Desmodium gangeticum. Cell line studies showed significant increase in ROS generation, dissipation of [INCREMENT]?m and PTP opening in isoproterenol treated cells. Desmodium was found to attenuate isoproterenol-induced hypertrophy by reduction of ROS generation, restoration of [INCREMENT]?m and prevention of PTP opening. This study is the first documentation of the modulatory effect of Desmodium gangeticum on cardiac hypertrophy.

DHARA ID: D054106 Pubmed ID: 23052030


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