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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Natural Product Research
2004
Aug
;
(4)
:0
Inhibitory activity of diarylheptanoids on farnesyl protein transferase.
Kang HM
,
Son KH
,
Yang DC
,
Han DC
,
Kim JH
,
Baek NI
,
Kwon BM
Abstract
Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and a new cyclic diarylheptanoid (6) and a known Compound 7 were isolated from fruits of Alnus japonica Steud. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FPTase) with an IC50 of 29-50 microM. The other compounds very mildly inhibited FPTase, therefore, the inhibitory activity on FPTase very much depends on the structure of diarylheptanoids.
DHARA ID:
D046558
Pubmed ID:
15214479
Access to Full Paper Not Available
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