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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of chromatography. B, Biomedical sciences and applications
2000
May
;
(2)
:0
Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction.
Fukuda K
,
Guo L
,
Ohashi N
,
Yoshikawa M
,
Yamazoe Y
Abstract
A method for the determination of three furocoumarins containing two new chemicals (GF-I-1 and GF-I-4) in commercially available grapefruit juice and grapefruit itself was developed using high-performance liquid chromatography (HPLC). These components isolated from grapefruit juice have 5-geranyloxyfurocoumarin dimer structures showing extremely high affinities for a form of cytochrome P450 (CYP3A4). Considerable differences were observed on the contents among commercial brands and also batches. The contents were determined to be 321.4+/-95.2 ng/ml GF-I-1, 5641.2+/-1538.1 ng/ml GF-I-2 and 296.3+/-84.9 ng/ml GF-I-4 in twenty-eight white grapefruit juices. These chemicals were not detected in beverages from orange, apple, grape and tangerine, except that trace amount of GF-I-2 and GF-I-4 were found in lemon juice. The average levels of these furocoumarins were lower in the juice from red grapefruit than a white one. The highest level of these components were found in the fruit meat.
DHARA ID:
D041952
Pubmed ID:
10872589
Access to Full Paper Not Available
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