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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Cancer Letters
2002
Sep
;
(1)
:0
Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake.
Miyata M
,
Takano H
,
Takahashi K
,
Sasaki YF
,
Yamazoe Y
Abstract
The influence of grapefruit juice intake on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced colon DNA damage was examined using comet assay in F344 rats given 60 mg/kg of PhIP by gavage. F344 rats allowed free access to grapefruit juice for 5 days experienced clearly reduced DNA damage in the colon to a 40% level of control rats. The suppression of PhIP-induced colon DNA damage depended on the grapefruit juice concentrations. The serum concentration of PhIP was compared between grapefruit juice-pretreated and non-pretreated rats, but showed no significant difference in the areas under their concentration-time curves, peak values and half lives of PhIP. Furthermore, no obvious difference was found in the liver capacity for mutagenic activation of PhIP in Ames assay between grapefruit juice-pretreated and non-pretreated rats. These results suggest that grapefruit juice suppresses PhIP-induced colon DNA damage by a mechanism independent of PhIP absorption in the intestine.
DHARA ID:
D041537
Pubmed ID:
12049810
Access to Full Paper Not Available
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